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Annie N. Samraj, Kimberly A. Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J. Gregg, Sandra L. Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk
www.plosone.org
www.plosone.org
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241.5685 602.3055 m
251.0929 602.3055 l
h
f*
435.1748 576.3402 m
439.937 576.3402 l
h
f*
316.9701 563.3008 m
321.7323 563.3008 l
h
f*
434.6646 563.3008 m
444.189 563.3008 l
h
f*
249.9591 511.3134 m
259.4268 511.3134 l
h
f*
502.0724 498.3307 m
511.5969 498.3307 l
h
f*
537.1087 446.3433 m
546.6331 446.3433 l
h
f*
437.1024 407.3386 m
446.6268 407.3386 l
h
f*
444.189 355.3512 m
453.7134 355.3512 l
h
f*
507.8551 316.3465 m
517.3228 316.3465 l
h
f*
522.5386 316.3465 m
532.0063 316.3465 l
h
f*
266.4567 290.3244 m
275.9811 290.3244 l
h
f*
281.1402 290.3244 m
290.6646 290.3244 l
h
f*
409.4362 264.3024 m
418.9606 264.3024 l
h
f*
203.4142 251.3197 m
212.9386 251.3197 l
h
f*
267.4772 251.3197 m
276.9449 251.3197 l
h
f*
279.2126 251.3197 m
288.737 251.3197 l
h
f*
357.222 238.337 m
366.7465 238.337 l
h
f*
244.4031 225.2976 m
253.9276 225.2976 l
h
f*
395.0929 225.2976 m
404.6173 225.2976 l
h
f*
460.6299 121.3228 m
470.1543 121.3228 l
h
f*
203.4142 95.3008 m
212.9386 95.3008 l
h
f*
215.1496 95.3008 m
224.674 95.3008 l
h
f*
296.9575 95.3008 m
306.4819 95.3008 l
h
f*
395.7732 95.3008 m
405.2409 95.3008 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(common)Tj
3.8437 0 Td
(sialic)Tj
2.2167 0 Td
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(12)Tj
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()Tj
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(14)Tj
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(15)Tj
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(16)Tj
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3.4866 0 Td
(fusion-medi-)Tj
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(6)Tj
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1.474 0 Td
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(17)Tj
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([)Tj
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(18)Tj
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(].)Tj
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1.9956 0 Td
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(consumption)Tj
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-34.1856 -1.2983 Td
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5.4594 0 Td
(foods)Tj
2.4095 0 Td
(\(mainly)Tj
3.3335 0 Td
(red)Tj
1.542 0 Td
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(endothelia)Tj
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(cancers)Tj
3.2031 0 Td
(\(carcinomas\))Tj
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([)Tj
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(8)Tj
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1.7291 0 Td
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5.7316 0 Td
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2.931 0 Td
([)Tj
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(19)Tj
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(].)Tj
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(that)Tj
1.7801 0 Td
(Neu5Gc)Tj
3.5207 0 Td
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(xeno-autoantigen,)Tj
8.2771 0 Td
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(not)Tj
1.576 0 Td
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-36.3682 -1.2983 Td
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2.058 0 Td
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4.49 0 Td
(anti-Neu5Gc)Tj
5.4198 0 Td
(polyclonal)Tj
4.354 0 Td
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4.3597 0 Td
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-34.1686 -1.3039 Td
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3.1521 0 Td
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(20)Tj
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(21)Tj
0 g
(].)Tj
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[()31()6()2()6( )11(\n)10()18()4(\r)12()-4()]TJ
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[()12()11()-36(\r)12()4()2()-3()6()]TJ
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(normal)Tj
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([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
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(autoimmunity)Tj
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([)Tj
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(22)Tj
0 g
(].)Tj
2.0749 0 Td
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(the)Tj
1.4684 0 Td
(primary)Tj
3.4582 0 Td
(dietary)Tj
-34.7071 -1.3039 Td
(source)Tj
2.8346 0 Td
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1.0148 0 Td
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3.5206 0 Td
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0.8447 0 Td
(red)Tj
1.5477 0 Td
(meat)Tj
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(\(muscle)Tj
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(mammalian)Tj
5.0399 0 Td
(origin\),)Tj
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(a)Tj
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(factor)Tj
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-34.2706 -1.2983 Td
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(heart)Tj
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(disease,)Tj
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(stroke,)Tj
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(type)Tj
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(2)Tj
0.6973 0 Td
(diabetes)Tj
3.464 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
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